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Indika N-LR, Frye RE, Rossignol DA, Owens SC, Senarathne UD, Grabrucker AM, Perera R, Engelen MP, Deutz NEP (2023) The rationale for vitamin, mineral, and cofactor treatment in the precision medical care of autism spectrum disorder

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However, RCTs utilize varying restrictive inclusion (e.g., age, disease severity) and exclusion (e.g., comorbidities, concomitant medications) criteria, leading to variabilities between patients in RCTs and those in the real world